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KMID : 0378119900170010327
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Chungnam Medical Journal
1990 Volume.17 No. 1 p.327 ~ p.331
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Resolution of Experimental Vitreous Hemorrhage with Tissue Plasmingogen Activator
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Abstract
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Tissue plasminogen activator(tPA) is a fibrin-specific fibrinolytic agent that has recently been shown to be effective in accelerating the clearance of hyphema. Intravitreal injection of tPA can promote repid lysis of experimental intravitreal fibrin clots. The purpose of this study was to investigate the efficacy of intravitreal tPA injection for the treatment of vitreous hemorrhage in the phakic non-vitrectomized rabbit eyes. Vitreous hemorrhages were produced by intravitreal injections of 0.55ml of autologous whole blood in twenty-five rabbit eyes with intact vitreous. The injection of 25 or 100 microgram of tPA in fifteen eyes resulted in the clearance of vitreous hemorrhage in 99± 19 or 34± 6.5 days respectively. This was significantly faster than control eyes in which the clearance was not seen until 131± 17 days later. No tractional retinal datachment was observed.
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